34. Multifunctional Silica Nanoparticles for Covalent Immobilization of Highly Sensitive Proteins

A convenient reverse micellar one-pot reaction yields multifunctional silica nanoparticles, which can be tailored to effectively suppress non-specific adsorption and, at the same time, enable efficient specific covalent immobilization of proteins. Using two highly sensitive proteins, it is demonstrated that the new particles provide a suitable micro-environment to maintain the protein's activity.